Romanian Society of Pharmaceutical Sciences
 

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SPECTRAL AND PHOTOCHEMICAL PROPERTIES OF HYPERBRANCHED NANOSTRUCTURES BASED ON GARDIQUIMOD AND TPPS4

DANIEL BODA1#, CAROLINA NEGREI2#*, ANDREEA-LETIŢIA ARSENE2#, CONSTANTIN CĂRUNTU3,4#, DUMITRU LUPULEASA2#, RODICA-MARIANA ION5,6#

1.Dermato-oncology Excellence Research Centre “Carol Davila” University of Medicine and Pharmacy, 22-24, Gr. Manolescu Street, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
3.Immunology Department, "Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei Street Bucharest, Romania
4.Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 8 Blvd. Eroii Sanitari, Bucharest, Romania
5.National Institute of Research&Development for Chemistry and Petrochemistry - ICECHIM, 202 Splaiul Independentei Street, Bucharest, Romania
6.Valahia University, Targoviste, Romania, Materials Engineering Dept. 18-20 Blvd. Unirii, Targoviste, Romania

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This paper examines certain experimental studies on photophysical (absorption maxima, molar absorption coefficient) and photochemical (singlet oxygen quantum yield) properties of Gardiquimod (GIQ) and its complex with 5,10,15,20-tetra-psulphonato- phenyl-porphyrin (TPPS4), as new photosensitizer agent in photodynamic therapy (PDT). The absorption spectra and atomic force microscopy are used, highlighting the complex between both compounds, and its nanometric size.