Romanian Society of Pharmaceutical Sciences
 

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PELARGONIUM SP.: CHARACTERIZATION OF THE POLYPHENOLS AND THEIR BIOLOGICAL POTENTIAL

CRISTINA IANCU1, OANA CIOANCĂ2, CORNELIA MIRCEA1*, MADALINA MOCANU3, MONICA HĂNCIANU2

“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, 16 Universităţii Street, 700115, Iași, Romania
1.Department of Pharmaceutical Biochemistry and Clinical Laboratory
2.Department of Pharmacognosy
3.Department of Physiopathology

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The current study regards the correlation between the biologic activity of two Pelargonium species and the spectra of the most important compounds of the samples. Pelargonium zonale and P. hispidum were not intensely studied, that is why the aim of the study was to correlate the chemical composition - antioxidant activity (DPPH, ABTS, reducing power assays) with the membrane stability of human blood cells. The methanolic extracts were spectrophotometrically analysed (polyphenols and flavonoids) and by using HPLC methods. We calculated the EC50 to evaluate the antioxidant activity. Although the differences of the chemical composition of the investigated extracts are not so obvious, Pelargonium zonale is twice more active than Pelargonium hispidum, fact also sustained by the HPLC results. The stability of the red blood cells proved that, at a low concentration, the extracts have a cytoprotective effect.