Romanian Society of Pharmaceutical Sciences
 

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INVESTIGATION OF ANTIOXIDANT AND ANTIMICROBIAL POTENTIAL OF SOME EXTRACTS FROM HEDERA HELIX L.

CARMEN ELENA POP 1#, MARCEL PÂRVU 2#, ANDREEA LETIȚIA ARSENE 3#*, ALINA ELENA PÂRVU 4#, DAN CRISTIAN VODNAR 5#, MONICA TARCEA 6#, ANCA MARIA TOIU 7#, LAURIAN VLASE 8#

1.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Drug Industry and Pharmaceutical Biotechnology, 8 Victor Babeș Street, Cluj-Napoca, Romania
2.“Babeș - Bolyai” University, Faculty of Biology and Geology, Department of Biology, 42 Republicii Street, Cluj-Napoca, Romania
3.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of General and Pharmaceutical Microbiology, 6 Traian Vuia Street, District 2, Bucharest, Romania
4.“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Medicine, Department of Pathophysiology, 3 Victor Babeș Street, Cluj-Napoca, Romania
5.University of Agricultural Sciences and Veterinary Medicine, Faculty of Food Science and Technology, Department of Food Science, 3-5 Mănăștur Street, Cluj-Napoca, Romania
6.University of Medicine and Pharmacy, Faculty of Medicine, Department of Community Nutrition and Food Safety, 38 Gheorghe Marinescu Street, Târgu Mureș, Romania
7.“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacognosy, 8 Victor Babeș Street, Cluj-Napoca, Romania
8.“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 8 Victor Babeș Street, Cluj-Napoca, Romania

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The aim of this study was the investigation of the antioxidant and the antimicrobial potential of some ethanolic extracts from Hedera helix (leaves, flowers, immature and ripe fruits) and the correlation with the profile of polyphenols, using an LC/MS method. In all samples, the chlorogenic acid, isoquercitrin, rutin and quercetin have been identified. The DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) were used to evaluate the antioxidant effects and the results showed a better antioxidant activity for H. helix ripe fruits ethanolic extract and a positive correlation between antioxidant effects, polyphenolic and flavonoid contents. The antimicrobial effect was tested using six bacterial strains and the microdilution method. The immature fruits extract showed a significant antibacterial activity against Staphylococcus aureus, while both immature fruits and flowers extracts possess a good antibacterial activity against Listeria monocytogenes.