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INFLUENCE OF RESIDUAL DIURESIS ON CARDIAC BIOMARKER NTproBNP IN CHRONIC HEMODIALYSIS PATIENTS

ANA-MARIA NECHITA1#, SILVIU PIȚURU2#, DANIELA RĂDULESCU1,3# ILEANA PERIDE1,3#, LUCIAN NEGREANU4,5#, ANDREI NICULAE1#, DUMITRU FERECHIDE6#, IONEL ALEXANDRU CHECHERIȚĂ1,3#*, RUXANDRA DIANA SINESCU7,8#

1.Department of Nephrology and Dialysis, “St. John” Emergency Clinical Hospital, 13th Vitan-Bârzești Road, 042122, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy Bucharest, 37th Dionisie Lupu Street, 020022, Bucharest, Romania
3.Clinical Department No. 3, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37th Dionisie Lupu Street, 020022, Bucharest, Romania
4.Department of Internal Medicine II – Gastroenterology, Emergency University Bucharest, 169th Splaiul Independentei, 050098, Bucharest, Romania
5.Clinical Department No. 5, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37th Dionisie Lupu Street, 020022, Bucharest, Romania
6.Department of Physiology I, Clinical Department No. 2, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37th Dionisie Lupu Street, 020022, Bucharest, Romania
7.Department of Plastic Surgery and Reconstructive Microsurgery, “Elias” Emergency University Hospital Bucharest, 17th Mărăști Boulevard, 011461, Romania
8.Clinical Department No. 11, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37th Dionisie Lupu Street, 020022, Bucharest, Romania

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High levels of cardiac biomarker N-terminal probrain type natriuretic peptide (NTproBNP) are present in hemodialyzed population and are associated with increased cardiovascular morbidity and mortality risks. Factors influencing the increase of NTproBNP and its significance in dialysis patients are still a matter of debate. We conducted a study on a cohort of 3 months-old chronic hemodialyzed patients in order to reveal the relationship between NTproBNP levels and residual diuresis, volume status, intradialysis ultrafiltration (UF), left ventricular ejection fraction (LVEF). Weekly, for 3-months, we measured for each patient the following parameters: NTproBNP levels, volemic status, UF rate and LVEF, before and after the first hemodialysis session in the week. The comparison between the three groups was discussed and analyzed. There was a significant inverse correlation between NTproBNP values and diuresis in all three studied groups, both before and after the dialysis sessions.