Romanian Society of Pharmaceutical Sciences
 

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EXPERIMENTAL PHARMACOLOGICAL RESEARCH REGARDING THE EFFECT OF SOME NEWLY SYNTHESIZED Β-PHENYLETHYL AMINES ON THE MODIFIED PARAMETERS OF THE LIPID METABOLISM

EMIL ȘTEFĂNESCU 1#, ELENA MOROȘAN 2#, HOREA GURGU 3#, ISABEL CRISTINA VIORICA GHIȚĂ 4#, ANCA ZANFIRESCU 1*, CRISTINA ELENA ZBÂRCEA 1, OVIDIU MUȘAT 5, SIMONA NEGREȘ 1

1.Pharmacology and Clinical Pharmacy Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.Clinical Laboratory and Food Hygiene Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
3.Pharmaceutical Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
4.Pharmacology Department, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474, Bucharest, Romania
5.Central Military Emergency Hospital,139 Calea Plevnei Street, 010825, Bucharest, Romania

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The effect of some new β-phenylethylamine derivatives on some parameters of the lipid metabolism and lipid peroxidation was investigated. The research method used was based on inducing hyperlipidaemia in rats by administering orally 4% triton in a dose of 400 mg/kg bw. The new compounds were tested against fenofibrate, the reference substance. The results have shown that compounds coded C2 and A1 induced a decrease in the total cholesterol levels, that was higher than that generated by the reference substance, compared to the control group with hyperlipidaemia. Furthermore, compounds coded C2, A6 and C3 have lowered LDL-cholesterol levels more efficiently than fenofibrate, in the hyperlipidaemia control group. All compounds except for C1 increased HDL-cholesterol levels more than the reference substance in the hyperlipidaemia control group. All compounds lowered the malonyl dialdehyde liver concentration, as a biomarker of lipid peroxidation, compared to the hyperlipemic control group. According to our results, the newly synthesized β-phenylethylamine derivatives have a statistically significant positive impact on the parameters of the lipid metabolism, possibly due to a β3- adrenergic receptors agonist mechanism.