Romanian Society of Pharmaceutical Sciences
 

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DETERMINATION OF IBUPROFEN BASED ON SCREEN-PRINTED ELECTRODES MODIFIED WITH CARBON NANOFIBERS

IRINA MIRELA APETREI 1, ADRIANA AURORA BEJINARU 2, MONICA BOEV 1, CONSTANTIN APETREI 3*, OLIMPIA DUMITRIU BUZIA 1

1.Department of Pharmaceutical Sciences, Medical and Pharmaceutical Research Centre, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galați, Romania
2.Department of Dental Medicine, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galați, Romania
3.Department of Chemistry, Physics and Environment, “Dunărea de Jos” University of Galați, Romania

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Electrochemical determination of ibuprofen has been employed by cyclic voltammetry and differential pulse voltammetry, using a screen-printed carbon electrode modified with carbon nanofibers. The mechanism of the oxidation process for ibuprofen is controlled by diffusion. A well-defined anodic oxidation peak has been obtained at + 1.08 V vs. Ag in 0.2 M acetate buffer (pH 4.5). The quantitative determination of ibuprofen has been conducted in optimal experimental conditions by differential pulse voltammetry, in the linear range between 8 × 10-7 M and 3 × 10-5 M and a detection limit of 3.5 × 10-7 M was established. The sensor has shown stability and good reproducible voltammetric response, which recommends its use in the analysis of pharmaceutical products. The quantity of ibuprofen acquired in the analysis of pharmaceutical products is compliant with the quantities obtained by using the usual methods.