Romanian Society of Pharmaceutical Sciences
 

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DESIGN AND OPTIMIZATION OF FAST DISPERSIBLE FORMULATIONS OF MULTI STRENGTH MELOXICAM TABLETS USING RESPONSE SURFACE METHODOLOGY

HUMA ALI 1*, FARYA ZAFAR 2, SOHAIL KHAN 3, RIFFAT YASMEEN 4, RABIA BUSHRA 4, SABA AIJAZ BALOCH 3

1.Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
2 .Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
3 .Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan
4 .DCOP, Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

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The purpose of the current study was to design, develop and optimize fast dispersible tablets (FDT) of meloxicam 7.5 mg and 15 mg. For this, CCRD was used with Design Expert® software. Nine diverse formulations, each of strength (MA1 - MA9; MB1 - MB9) (F1 - F9) were designed, with two independent variables, including (X1) Croscarmellose (Ac-Di-Sol) (4 - 10%), (X2) Microcrystalline cellulose (Avicel PH-102) (50 - 65%) at five different levels (1, -1, 0, β, -β). Disintegration time (Y1) and hardness (Y2) were chosen as responses variables. Powder blends of these trial compositions were evaluated for micromeritic parameters and finally six formulations from each batch were qualified for compression stage. The selected formulations were compressed by direct compression procedure. Tablet fill was improved by aspartame, incorporated as a sweetener. Different compendial and non-compendial tests were carried out to determine the quality attributes of FDT of Meloxicam and the results were observed within the adequate values. MA6 and MB6 were selected as the preeminent optimized products on the basis of micromeritic and physicochemical features. MA6 and MB6 have shown quicker disintegration time i.e. 18 sec; 19 sec and optimal percentage release of drug i.e., 99.38 ± 0.86%; 99.86 ± 0.91% and drug recovery (assay) values as 100.76 ± 0.52%; 100.01 ± 0.84% respectively. Correspondingly, predicted and actual values of hardness and disintegration time were found in good correlation. FDTs of Meloxicam were successfully developed using RSM tool, which was found valuable in discovering the consequences of numerous variables on drug processability.