Romanian Society of Pharmaceutical Sciences

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CHEMOTHERAPY-INDUCED CARDIOTOXICITY IN ONCOLOGY DRUGS INVOLVED AND CLINICAL ASSESSMENT

SIMONA SORANA CĂINAP1,2, VIORICA NAGY1,3, CĂLIN CĂINAP1,3*

1.University of Medicine and Pharmacy, 8 Victor Babeş Street, 400012 Cluj-Napoca, Romania
2.Emergency County Hospital for Children, 68 Moților Street, 400370, Cluj-Napoca, Romania
3.Institute of Oncology “I. Chiricuță”, 34 - 36 Republicii Street, 400015, Cluj-Napoca, Romania

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Cancer represents an important public health challenge worldwide due to the continuous increase of its incidence. The general prognosis is more and more favourable with new treatments which allow long survival. Chemotherapeutical treatments affect the patients, one of the most important issues being represented by cardiotoxicity, which is low responsive to conventional treatments and finally will determine the survival rate. In this paper we discuss the chemotherapeutical category of agents incriminated to produce cardiac toxicity and the workup indicated for an early diagnostic.