Romanian Society of Pharmaceutical Sciences
 

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BIOLOGICAL EVALUATION OF CHITOSAN-ANTIDIABETIC DRUG FORMULATIONS FOR THE TREATMENT OF DIABETES MELLITUS

FLORENTINA GIANINA LUPAŞCU 1, IUSTINA AVRAM 1, LUMINIŢA CONFEDERAT 1, SANDRA MĂDĂLINA CONSTANTIN 1, CRISTINEL IONEL STAN 2*, ELENA CĂTĂLINA LUPUŞORU 3, ALEXANDRU SAVA 1, LENUŢA PROFIRE 1

1.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
2.Department of Morphofunctional Science I, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
3.Department of Morphofunctional Science II, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania

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The aim of this study was to investigate the biological effects of some chitosan-antidiabetic drug formulations on diabetes mellitus induced with streptozotocin to rats. The biochemical parameters such as glycaemia, glycosylated haemoglobin and hepatic, renal and lipid metabolism parameters were investigated. The food and water intake and body weight were also monitored as clinical parameters. The results showed that chitosan-antidiabetic drug formulations (chitosan-metformin: CS-M, chitosan-glibenclamide: CS-G, chitosan-metformin-glibenclamide: CS-MG) improved the biochemical and clinical parameters of diabetic rats which shows the beneficial effects of chitosan for diabetes mellitus treatment. The best results were obtained with CS-MG for which there were recorded the best hypoglycaemic effect in comparison with CS-M and CS-G. This polymeric system also showed good values for blood glycosylated haemoglobin (HbA1c), biochemical liver and renal function parameters: ALT, AST, LDH, total bilirubin, direct bilirubin and urea, creatinine and uric acid respectively.