Romanian Society of Pharmaceutical Sciences
 

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ANTIOXIDANT EVALUATION OF SOME COUMARIN DERIVATIVES

GABRIELA TATARINGA1, CATALINA STAN2*, CORNELIA MIRCEA3, ALEXANDRA JITAREANU1, ANA-MARIA ZBANCIOC1

1.Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania
2.Department of Pharmaceutical Industry, Faculty of Pharmacy, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania
3.Department of Pharmaceutical Biochemistry and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania

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The present study evaluated the antioxidant potential of 28 coumarin derivatives, using three antioxidant assays: DPPH inhibition, total reducing power and NO inhibition. Out of the tested compounds, the most active DPPH free radicals scavengers were the coumarin hydrazide derivatives. These substances were also the only ones among the investigated derivatives that exhibited a moderate reducing power of ferricyanide to ferrocyanide, but their activity was inferior to that exhibited by the reference substance (ascorbic acid). Most of the tested substances were moderate NO inhibitors. The activity of 4-methyl-7-methoxy coumarin was remarkable, exceeding the inhibitory potential of ascorbic acid.