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ANTIOXIDANT ACTIVITY AND DRUG PROFILE OF SEVERAL THIOUREA DERIVATIVES OF 2-THIOPHENE CARBOXYLIC ACID

TEODORA COSTEA 1#, CARMELLINA DANIELA BĂDICEANU 2*, DIANA CAMELIA NUȚĂ 2, CERASELA ELENA GÎRD 1, CARMEN LIMBAN 2, OANA KARAMPELAS 3#, SPERANȚA AVRAM 4

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacognosy, Phytochemistry and Phytotherapy, 6 Traian Vuia Street, Bucharest, 020956, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 6 Traian Vuia Street, Bucharest, 020956, Romania
3.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, 6 Traian Vuia Street, Bucharest, 020956, Romania
4.University of Bucharest, Faculty of Biology, Department of Anatomy, Animal Physiology and Biophysics, 36-46 M. Kogălniceanu Boulevard, 050107, Bucharest, Romania

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Oxidative stress plays an important role in the development of several diseases (cancer, stroke, diabetes etc.). Therefore, the discovery of new compounds with antioxidant activity and a safe pharmacological profile has become an area of great interest. The aim of our study was the evaluation of antioxidant capacity and drug profile of several 2-thiophene carboxylic acid thiourea derivatives. The antioxidant activity was determined by means of scavenger activity towards 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) free radicals and ferric reducing power assay. The pharmacological profile of the analysed compounds was evaluated by in silico protocols (bioavailability, pharmacokinetics etc.). The electronic and steric molecular descriptors of the thiourea derivatives have been also determined. According to our results, all compounds showed antioxidant activity. For the most part, in silico studies revealed a safe pharmacological profile for the analysed compounds.