Romanian Society of Pharmaceutical Sciences
 

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ACUTE POSTOPERATIVE PAIN AND ANALGESICS CONSUMPTION IN ORAL AND MAXILLOFACIAL SURGERY

IRINA CAZACU1*, DANIEL-CORNELIU LEUCUTA2, MIHAELA BACIUT3, GRIGORE BACIUT3, CRISTINA MOGOSAN1, FRANÇOISE HARAMBURU4, ANNIE FOURRIERRÉGLAT5, FELICIA LOGHIN6

1.Department of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
2.Department of Medical Informatics and Biostatistics, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
3.Department of Maxillofacial Surgery and Implantology, Faculty of Dentistry, Clinic of Oral and Maxillofacial Surgery, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
4.Regional Pharmacovigilance Centre, CHU de Bordeaux, INSERM U657, Department of Pharmacology, Bordeaux 33000, France
5.University of Bordeaux, INSERM U657, Department of Pharmacology, Bordeaux 33000, France
6.Department of Toxicology, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania

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The aims of this study were to investigate the presence of postoperative pain in oral and maxillofacial surgery and to determine predictive factors for postoperative pain and analgesics consumption. A prospective observational study was conducted on patients admitted for surgery at the Clinic of Oral and Maxillofacial Surgery from Cluj-Napoca. Patients (n = 104) had a median age of 49.5 years old (interquartile range: 28-61). Surgery mainly consisted of tumour excision (41.4%) and oral surgery (22.1%), and postoperative analgesia was mainly assured by metamizole (38.4%) and ketoprofen (36.4%). Moderate-to-severe postoperative pain was reported by 44.2% of the patients. Psychological status and type of surgery were both correlated with postoperative pain and analgesic consumption. Identifying factors that could predict the presence of postoperative pain or the analgesic consumption helps initiate a prompt and effective pain treatment.