Romanian Society of Pharmaceutical Sciences

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A QUALITY-BY-DESIGN APPROACH FOR OPTIMISATION OF DOCETAXEL TRANSFEROSOMAL FORMULATIONS

FLORENTINA-IULIANA COCOȘ 1,2, RĂZVAN-MIHAI PRISADA 1,2*, VALENTINA ANUȚA 1,2, LĂCRĂMIOARA POPA 1,2, MIHAELA-VIOLETA GHICA 1,2, RADU-CLAUDIU FIERĂSCU 3,4, BOGDAN TRICĂ 3, CRISTIAN-ANDI NICOLAE 4, CRISTINA-ELENA DINU-PÎRVU 1,2

1 Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania
2 Innovative Therapeutic Structures Research and Development Centre (InnoTher), “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
3 National Institute for Research & Development in Chemistry and Petrochemistry – ICECHIM Bucharest, 202 Spl. Independenței, 060021, Bucharest, Romania
4 Faculty of Chemical Engineering and Biotechnology, “Politehnica” National University of Science and Technology Bucharest, 1-7 Gh. Polizu Street, 011061, Bucharest, Romania

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This research investigated the design, characterization and optimization of docetaxel-loaded transfersomes for enhanced transdermal delivery in the treatment of skin cancer. A systematic formulation development approach, guided by the principles of Design of Experiments (DoE) and One Factor At a Time (OFAT), was employed to optimize the formulation parameters. Physicochemical properties including particle size, polydispersity index (PDI), zeta potential and entrapment efficiency were comprehensively assessed to ensure the stability and drug-loading capacity of the transfersomes. Morphological analysis using Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) confirmed well-defined transfersome structures. In vitro release kinetics studies demonstrated a controlled and sustained release profile of Docetaxel from the transfersomes, highlighting its potential for enhanced therapeutic efficacy.