A NEW ERA FOR THE THERAPEUTIC MANAGEMENT OF THE ONGOING COVID-19 PANDEMIC
ANDREEA LETIȚIA ARSENE 1#, ION-BOGDAN DUMITRESCU 1#, CRISTINA MANUELA DRĂGOI 1#, DENISA IOANA UDEANU 1*, DUMITRU LUPULIASA 1, VIOREL JINGA 1, DOINA DRĂGĂNESCU 1, CRISTINA ELENA DINU-PÎRVU 1, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU 1#, IONUȚ EMILIAN BLEJAN 1, RALUCA ELISABETA MOISI 1, ALINA CRENGUȚA NICOLAE 1, HORAȚIU MOLDOVAN 2, DANIELA ELENA POPA 1, BRUNO ȘTEFAN VELESCU 1, SIMONA RUȚĂ 1
1. “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
2. Ministry of Health, 1-3 Cristian Popişteanu Street, 010024, Bucharest, Romania
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Three zoonotic coronaviruses emerged at the beginning of the XXI century: SARS-CoV (Severe Acute Respiratory Syndrome coronavirus), Middle-East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV2 (previously known as 2019-nCoV), the etiologic agent of COVID 19 (Coronavirus disease) pandemic. The outbreak of the COVID-19 started in Wuhan, Hubei province, China, in December 2019 and has spread extremely fast worldwide. The World Health Organization declared it a pandemic on 11 March 2020. The present study is reviewing the background of human coronaviruses, the potential viral reservoirs, the main genomic and pathogenic aspects of SARS-CoV-2 and the actual data on the immunopathological mechanisms of COVID 19, looking towards therapeutic approaches for SARS-CoV2 infection.