Farmacia Journal 5/2026
Volume 74 | Number 5 | Year 2026
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LIPOSOMES AND ADVANCED VESICULAR SYSTEMS FOR TRANSDERMAL DELIVERY: OVERCOMING THE SKIN BARRIER
CEMRE IREM AYGULER *, BASAK ACUNER
Department of Pharmaceutical Technology, Faculty of Pharmacy, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Türkiye
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EFFICACY AND SAFETY OF TIROFIBAN IN THE TREATMENT OF ACUTE ISCHEMIC STROKE BASED ON WEB OF SCIENCE DATABASE: A META-ANALYSIS
RUI ZHANG 1*, ZHIYUN WANG ¹
¹ Department of Neurology, Tianjin First Central Hospital, Tianjin, 300192, China
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COMPARATIVE TOXICOLOGICAL EVALUATION OF VERONICA AND SALIX EXTRACTS USING DAPHNIA PULEX AND HETEROCYPRIS INCONGRUENS
ALEXANDRA MIHAELA PAȘITONIU 1,2, CORINA CORNET 1*, CERASELA ELENA GÎRD 1, GEORGIANA NIȚULESCU 1, COSMINA-GABRIELA DUȚĂ-BRATU 1, DUMITRU LUPULIASA 1, GEORGE MIHAI NIȚULESCU 1, OCTAVIAN TUDOREL OLARU ¹
¹ ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 Sereskin Concept SRL, Ilfov, Romania -
ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITIES OF POGOSTEMON CABLIN FROM NORTH KOLAKA: PRO-INFLAMMATORY CYTOKINE SUPPRESSION IN AN ACUTE INFLAMMATION MODEL AND GC-MS/MS-BASED METABOLITE PROFILING
ADRYAN FRISTIOHADY 1*, JAFRIATI 2, IRVAN ANWAR 1, LIDYA A. HARUNA 1, HARIANA 1, RATHAPON ASASUTJARIT 3, LA ODE MUH. JULIAN PURNAMA 3, SAHIDIN ¹
¹ Department of Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, Indonesia
2 Department of Public Health, Faculty of Public Health, Universitas Halu Oleo, Kendari, Indonesia
3 Thammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Bangkok, Thailand -
LC-MS/MS PHYTOCHEMICAL PROFILING AND IN VITRO ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF THE METHANOLIC EXTRACT OF ACACIA ARABICA
TEBIB ARBIA 1*, BOUHAFSOUN AICHA 1, ÇIFTÇI BEGÜM HAZAR 2, KELLAL HASSIBA 1, TAŞ KÜÇÜKAYDIN MELTEM 2, KÜÇÜKAYDIN SELÇUK 2, CHERIFI FADILA 1, MEHTOUGUI AMEL 1, DURU MEHMET EMIN 2, ERENLER RAMAZAN 3, DJABEUR ABDERREZAK ¹
¹ Laboratory of production and valorization of plants and microorganisms (LP2VM), Department of Biotechnology, Faculty of Natural and Life Sciences, University of Science and Technology of Oran - Mohamed Boudiaf USTO-MB, B.P. 1505, ElMn’aour, Oran 31000, Algeria
2 Mugla Sitki Kocman University Faculty of Science Department of Chemistry 48121 Muğla, Turkey
3 Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpaşa University, 60240 Tokat, Türkiye -
EVALUATION OF THE POLYPHENOLIC PROFILE AND THE IN VITRO ANTIOXIDANT POTENTIAL OF SEVEN GERANIUM SPECIES FROM THE ROMANIAN FLORA
ANCA TOIU 1, ANA-MARIA VLASE 2, LAURIAN VLASE 3*, MIHAELA-ANCUŢA NECHITA 1, ILIOARA ONIGA ¹
¹ Department of Pharmacognosy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania
2 Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeş Street, 400010, Cluj-Napoca, Romania
3 Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeş Street, 400010, Cluj-Napoca, Romania -
PHYTOCHEMICAL CHARACTERIZATION, ANTIOXIDANT POTENTIAL AND MULTIFUNCTIONAL ENZYME INHIBITORY ACTIVITY OF HYSSOPUS OFFICINALIS SUBSP. ARISTATUS: AN IN VITRO AND IN SILICO STUDY
TIJANA MIĆOVIĆ 1,2*, STEVAN SAMARDŽIĆ 3, IVONA VELIČKOVIĆ 4, KSENIJA MILESKI 4, JELENA ĐOROVIĆ JOVANOVIĆ ⁵
¹ Institute for Medicines and Medical Devices of Montenegro, Podgorica, Montenegro
2 Faculty of Medicine, University of Montenegro, Podgorica, Montenegro
3 Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
4 Institute of Botany and Botanical Garden “Jevremovac”, Faculty of Biology, University of Belgrade, Belgrade, Serbia
5 Institute for Information Technologies, University of Kragujevac, Kragujevac, Serbia -
OLIVE LEAF EXTRACT AMELIORATES HYPERGLYCAEMIA, OXIDATIVE STRESS AND PANCREATIC AND HEPATIC INJURY IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A DOSE-DEPENDENT COMPARISON WITH METFORMIN
ALAA TALAL QUMSANI 1*, MOHAMED EZZAT ELBEEH 1,²
¹ Department of Biology, Al-Jumum University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia
2 Department of Zoology, Faculty of Science, Mansoura University, Mansoura 35516, Egypt -
ANTIOXIDANT AND ANTIHYPERTENSIVE EFFECTS OF ELEUTHERINE BULBOSA (MILL.) CHITOSAN NANOPARTICLES IN NACL-INDUCED HYPERTENSIVE RATS
MOCH. SAIFUL BACHRI 1*, DIAN PRASASTI 1, DARU ESTININGSIH 2, MUHAMMAD MA’RUF 3, LAELA HAYU NURANI 1, NURI ARI EFIANA 1, MUHAMMAD ANDY RAJAB 1, AULIA SYAFADILLA AZALI 1, SYAHARANI AGUSTIN 1, AULIA AYU KUSUMANINGRUM 1, DANANG PRASETYANING AMUKTI 2, VIVI SOFIA ⁴
¹ Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia, 55164
2 Faculty of Health Sciences, Alma Ata University, Yogyakarta, Indonesia, 55183
3 Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Banjarmasin, Indonesia, 70123
4 Faculty of Pharmacy and Health, Universitas Tjut Nyak Dhien, Medan, Indonesia, 20123 -
QUERCETIN-INDUCED CYTOTOXICITY IN RPMI 7951 HUMAN MELANOMA CELLS: AN IN VITRO STUDY
DANIELA SAȘCO 1,2,3,4#, MONICA MARIA ȘUȘAN 5,6#, IOAN SMULTEA 1,2,3,4, RĂZVAN GEORGE RAESCU 1*, BOGDAN ALMAJAN-GUTA 7, ANDRA TIBERIA PĂCURAR 1,2,3,4, ANDREEA-MARIA CRISTEA 1,2,3,4, ALINA HEGHEȘ 2, VICTOR DUMITRAȘCU ⁸
¹ Doctoral School, “Victor Babeș” University of Medicine and Pharmacy of Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
2 Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
3 University Clinic of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
4 Research Center for Pharmaco-Toxicological Evaluation, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
5 Department of Internal Medicine, Discipline of Medical Semiology I, “Victor Babeș” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
6 Centre for Preventive Medicine, “Victor Babeș” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
7 Department of Physical Therapy and Special Motricity, West University of Timișoara, 300223, Timișoara, Romania
8 Biochemistry and Pharmacology Department, Discipline of Pharmacology, Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara, Romania -
ISOLATION OF ANTI-PROLIFERATIVE BIOACTIVE COMPOUNDS FROM GYPSOPHILA ERIOCALYX PLANT EXTRACTS BY ACTIVITY – GUIDED APPROACH
BUSRA GUNDOGDU 1,2,3, UMMUHAN DEMIR 1,4, HUSEYIN SERVI 5*, TIMUR HAKAN BARAK ⁶
¹ Science and Advanced Technologies Research Centre (BILTAM), Istanbul Medeniyet University, İstanbul, Türkiye
2 Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Yıldız Technical University, İstanbul, Türkiye
3 Faculty of Engineering and Natural Sciences, Sabancı University, İstanbul, Türkiye
4 Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, İstanbul, Türkiye
5 Department of Pharmacognosy, Faculty of Pharmacy, Istanbul Yeni Yuzyil University, İstanbul, Türkiye
6 Department of Pharmacognosy, Faculty of Pharmacy, Acibadem Mehmet Ali Aydinlar University, İstanbul, Türkiye -
RAPHANUS SATIVUS JUICE ALLEVIATES MERCURY-INDUCED MULTISYSTEM TOXICITY IN RATS: AN INTEGRATED BIOCHEMICAL, HISTOPATHOLOGICAL AND REPRODUCTIVE STUDY
LEILA BOUKHALFOUN 1*#, WAFA SIOUDA 1#, CHAHRAZED GHEFFAR 2, RACHIDA KIRDI 1, KHEIRA SLAMA 3, ABDERREZZAK KIROUANI 1#
¹ Laboratory of Nutrition, Biodiversity and Environment, Department of Agronomy, Faculty of Sciences, University of Médéa, 26000, Algeria
2 Laboratory of Materials and Environment (LME), Faculty of Technology, University of Médéa, Urban Pole, Médéa, 26000, Algeria
3 Laboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, Annaba, Algeria -
MECHANISM OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ AGONISTS IMPROVING INSULIN RESISTANCE IN GESTATIONAL DIABETES
XUEYU YIN *
Department of Obstetrics, Taiyuan Maternal and Child Health Hospital, Taiyuan, 030012, Shanxi, China
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ACALYPHA INDICA ATTENUATES OBESITY-INDUCED ADIPOSE AND VASCULAR INFLAMMATION VIA MODULATION OF ADIPOKINES AND ENDOTHELIAL ADHESION MOLECULES IN OBESE RATS
RANI WARDANI HAKIM 1,9,10*, DEWI SUKMAWATI 2, NUR RAHADIANI 3, AGIAN JEFFILANO BARINDA 4, DWI RAMADHANI 5, MUHAMMAD ROIL BILAD 6, TRI JULI EDI TARIGAN 7, SRI WIDIA A JUSMAN 8, ERNI H. PURWANINGSIH 1,9, NORMA NUR AZIZAH 9, RIA NUR PUSPA SARI ¹⁰
¹ Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
2 Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
3 Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
4 Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
5 Center for Radiation Safety Technology and Metrology, National Research and Innovation Agency/BRIN, Jakarta, Indonesia
6 Faculty of Integrated Technologies, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam
7 Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
8 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
9 Drug Development Research Center, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
10 Master’s Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia -
DISCHARGE PHARMACOTHERAPY PATTERNS AND MEDICATION BURDEN IN ISCHAEMIC STROKE PATIENTS WITH DOCUMENTED COGNITIVE DYSFUNCTION: A DESCRIPTIVE STUDY IN A ROMANIAN TERTIARY-CARE HOSPITAL
IRINA MARIA VLAD 1,2*, ŞTEFAN STRILCIUC 3, DAFIN FIOR MUREȘANU 1,2,4,5, LĂCRĂMIOARA PERJU-DUMBRAVĂ 1,⁴
¹ Doctoral School, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2 Department of Neurosciences, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
3 Department of Genomics, Medfuture Institute for Biomedical Research, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4 Neurology Clinic, Cluj County Emergency Clinical Hospital, Cluj-Napoca, Romania
5 RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania -
EFFECT OF RADIX SOPHORAE FLAVESCENTIS EXTRACT ON TREATMENT AND PROGNOSIS OF PATIENTS WITH WILMS TUMOR
WEIXIA MENG 1, MINGJUN ZHENG 1, LING LI 2*
¹ Department of Pediatrics, China Resources and Wisco General Hospital, 430080 Wuhan, Hubei, China
2 Department of Pathology, China Resources and Wisco General Hospital, 430080 Wuhan, Hubei, China -
NETWORK PHARMACOLOGY AND IN VITRO ANTI-S. EPIDERMIDIS EFFECTS OF QUERCETIN: COMPUTATIONAL INSIGHTS INTO IL-17 SIGNALLING AND NEUTROPHIL EXTRACELLULAR TRAPS
RAMESA SHAFI BHAT *, MONA SHUJAA ALHARBI, ABEER M. ALDBASS, SOOAD AL-DAIHAN
¹ Biochemistry Department, Science College of King Saud University, Riyadh, Saudi Arabia
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TECHNOLOGICAL DESIGN AND MULTI-ASSAY ANTIOXIDANT EVALUATION OF A QUERCETIN–RESVERATROL–BIOTIN FORMULATION
SORINEL MARIUS NEACȘU 1, OANA KARAMPELAS 1*, ADINA MAGDALENA MUȘUC 2, EMMA ADRIANA OZON 1, ELIZA OPREA 3,4, ADRIANA RUSU 2, SIMONA PETRESCU 2, JEANINA PANDELE CUSU 2, IZABELA DANA MARIA STAN 2, VASILE-ADRIAN SURDU 5, DUMITRU LUPULIASA 1, ADRIANA MIHAELA ILIEȘIU 1,⁶
¹ Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 Institute of Physical Chemistry - Ilie Murgulescu, Romanian Academy, Bucharest, Romania
3 Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania
4 Research Institute of the University of Bucharest—ICUB, University of Bucharest, Bucharest, Romania
5 Department of Materials Science, Faculty of Materials Science and Engineering, Transilvania University of Brașov, Brașov, Romania
6 Department of Internal Medicine and Cardiology, “Theodor Burghele” Clinical Hospital, Bucharest, Romania -
BRUCEA JAVANICA (L.) MERR. EXTRACT DOWNREGULATES MMP2 EXPRESSION AND REDUCES ENDOTHELIAL DENUDATION-INDUCED ARTERIAL NEOINTIMAL HYPERPLASIA IN MICE
CANDRA DWIPAYANA HAMDIN 1*, VANIA AISYAH AULIA SYAHDA HARIS 1, ANDRI FREDIANSYAH 2, ANGGIT L. SUNARWIDHI 1, EKA SUNARWIDHI PRASEDYA ³
¹ Study Program of Pharmacy, Faculty of Medicine and Health Sciences, University of Mataram, Mataram, Indonesia
2 Research Center for Food Technology and Processing (PRTPP), National Research and Innovation Agency (BRIN), Yogyakarta, Indonesia
3 Study Program of Biology, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, Indonesia -
BETULIN INDUCES CYTOTOXIC EFFECTS IN AN OSTEOSARCOMA CELL LINE
IOAN SMULTEA 1,2, ȘTEFANIA-IRINA DUMITREL 1,2,3#, JENEL MARIAN PĂTRAȘCU 4*, DANIELA SAȘCO 1,2, CASIANA BORU 5,⁶
¹ Doctoral School, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
2 Research Centre for Pharmaco-Toxicological Evaluations, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
3 Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
4 Department of Orthopedics-Traumatology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, Romania
5 Department of Medicine, University of Medicine and Pharmacy “Vasile Goldis”, 310045 Arad, Romania
6 Arad County Emergency Clinical Hospital, 310037 Arad, Romania -
EFFECT OF APOPTOZOLE ON CIRCULATING CYTOKINE LEVELS: AN EX VIVO WHOLE BLOOD STIMULATION STUDY
GHADA A. ALOTAIBI, JAWAHER ALSUGHAYYIR, MOHAMMAD A. ALFHILI *
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia
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MACHINE LEARNING-BASED PREDICTION OF ANTIBIOTIC SUSCEPTIBILITY TO SUPPORT PERSONALISED PHARMACOTHERAPY IN HOSPITALIZED PATIENTS: EVIDENCE FROM AN INDONESIAN REFERRAL HOSPITAL
IKHWAN YUDA KUSUMA 1*, MUHAMMAD SYAIFUL ALIIM 2, FIQIH NURKHOLIS 1, MUH.AKBAR BAHAR ³
¹ Pharmacy Study Program, Faculty of Health, Universitas Harapan Bangsa, 53182 Purwokerto, Indonesia
2 Department of Electrical Engineering, Faculty of Engineering, Universitas Jenderal Soedirman, 53371 Purbalingga, Indonesia
3 Department of Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, 90245 Makassar, Indonesia -
DISPROPORTIONALITY SIGNALS AND DELAYED-ONSET ADVERSE EVENTS ASSOCIATED WITH DAPRODUSTAT IN FAERS: CLINICAL PRIORITIZATION AND TEMPORAL ONSET PROFILING ACROSS CARDIOVASCULAR, THROMBOTIC, HEMATOLOGIC AND NEOPLASTIC EVENTS
AZFAR ATHAR ISHAQUI 1*, SHOAIB ALAM 2, JAVERIA FAROOQ 3, KHALID ORAYJ 1, MUHAMMAD IMRAN 4, SALMAN ASHFAQ AHMAD 4, RAYAH ASIRI 1, ADNAN IQBAL 2, MUHAMMAD BILAL MAQSOOD ⁵
¹ Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
2 Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
3 Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
4 Department of Pharmacy, Iqra University, Karachi, Pakistan.
5 Quality and Performance Administration, Eastern Health Cluster, Health Holding Company, Dammam, Saudi Arabia -
ANTIBIOTIC-RELATED BEHAVIORS AND PERCEIVED HEALTH CONSEQUENCES AMONG THE GENERAL POPULATION IN ARMENIA: A CROSS-SECTIONAL STUDY
LUSINE GAGIK NAZARYAN 1*, SYUZANNA TARON EPREMYAN 2, ANUSH BARSEGH BARSEGHYAN 1, MARTA HEKTOR SIMONYAN ¹
¹ Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
2 Scientific Centre of Drug and Medical Technology Expertise, Yerevan, Armenia -
PSYCHOTROPIC POLYPHARMACY AT PSYCHIATRIC DISCHARGE – PATTERNS OF BENZODIAZEPINE, Z-HYPNOTIC AND ANTIPSYCHOTIC CO-PRESCRIPTION
ALEXANDRU MISCHIE 1, LIANA DEHELEAN 2*, ALEXANDRA ENACHE 3, RAMONA AMINA POPOVICI 4, DORA MIHAELA CÎMPIAN 5, CRISTINA BODO 5, SONIA ȘUT 6, ADRIAN CIOLOCA 7, ELENA GABRIELA STRETE 8, ANDREEA SĂLCUDEAN ⁵
¹ Doctoral School, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
2 Department of Psychiatry, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
3 Discipline of Forensic Medicine, Bioethics, Deontology, and Medical Law, Department of Neuroscience, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania
4 Faculty of Dental Medicine, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania
5 Department of Bioethics, Medical Deontology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, Romania
6 Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Gheorghe Marinescu Street, No. 38, Târgu Mureș, Romania
7 Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Gheorghe Marinescu Street, No. 38, Târgu Mureș, Romania
8 Department of Psychiatry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania