Romanian Society of Pharmaceutical Sciences
 

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EFFECT OF FUCOIDAN, HABERLEA RHODOPENSIS AND PROPOLIS ON MOBILIZATION OF THE CD34+ STEM CELLS IN RATS

ELISAVETA G. APOSTOLOVA 1*, VESELA KOKOVA 1, ZHIVKO PEYCHEV 2, STELA PEYCHEVA 3, APOSTOL APOSTOLOV 4

1.Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University, Plovdiv, Bulgaria
2 .Department of Medical Informatics, Biostatistics and Interactive Education, Faculty of Public Health, Medical University, Plovdiv, Bulgaria
3 .Department of Paediatric Dentistry, Faculty of Dental Medicine, Medical University, Plovdiv, Bulgaria
4 .Department of Anaesthesiology and Intensive Care, “St. George” University Hospital, Plovdiv, Bulgaria

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We evaluated the influence of fucoidan, Haberlea rhodopensis (H. rhodopensis) and propolis on the hematopoietic stem cells (CD34+) levels into the blood stream of rats. Four groups of male Wistar rats (n = 10) were treated intraperitoneally as follows: 1st group – 0.9% NaCl; 2nd group – fucoidan (100 mg/kg b.w.); 3rd group – H. rhodopensis (50 mg/kg b.w.) and 4th group – propolis (100 mg/kg b.w.). Two hours after a single administration of the substances, blood samples were collected and analysed. We found a significant increase in the number of CD34+ cells in the blood stream after the administration of the tested substances. Fucoidan also caused a significant increase in the number of leukocytes compared to the control group. These results show that the tested substances could mobilize stem cells in the peripheral blood of rats. Fucoidan may increase the count of circulating white blood cells (WBC), H. rhodopensis decreases this value, while propolis does not influence leukocytes level in peripheral blood.