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PHYTOCHEMICAL PROFILING AND ANTIOXIDANT PROPERTIES OF AJANIA FASTIGIATA (C. WINKL.) POLJAKOV (ASTERACEAE)

ASEM MAMUROVA 1, GULZAT KAIRANOVA 1*, GAUKHAR AMERTAYEVA 1, NURSULU AKHTAYEVA 1, AHMET BEYATLI 2, LASHYN KIYEKBAYEVA 3, ZHANAR ISKAKOVA 4, KAIRAT ZHALDYBAEV 5, KLARA ZHUMALINA 5

1 Department of Biodiversity and Bioresources, al-Farabi Kazakh National University, Almaty, Kazakhstan
2 Department of Medicinal and Aromatic Plants, University of Health Science, Istanbul, Turkey
3 Pharmaceutical school, Asfendiyarov Kazakh National Medical University; Almaty, Kazakhstan
4 Research Institute of New Chemical Technologies ENU named after L.N. Gumilyov; Astana, Kazakhstan
5 Kazakh-Russian Medical University in Kazakhstan, Almaty, Kazakhstan

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This study aims to evaluate the phytochemical composition and antioxidant properties of Ajania fastigiata (C. Winkl.) Poljakov, a medicinal plant native to Kazakhstan. For the first time, a comprehensive GC-MS-based phytochemical profiling of this species was conducted, revealing a unique chemical composition. GC-MS analysis identified 26 bioactive compounds in the ethanol extract, with bicyclo[3,1,1]hept-3-en-2-ol, 4,6,6-trimethyl- (30.6%), hexadecanoic acid (11.0%) and 9,12,15-octadecatrienoic acid (10.7%) as the major constituents. The ethanol extract showed the highest total phenolic content (65.7 mg GAE/g) and flavonoid content (7.18 mg QE/g). Antioxidant activity, evaluated through DPPH and FRAP assays, demonstrated significant radical scavenging capacity (79.21% at 1 mg/mL) and reducing power (1.3727 OD at 1 mg/mL), comparable to gallic acid. The essential oil contained camphor, α-pinene and carvacrol. These findings highlight Ajania fastigiata as a promising natural source of antioxidants and support its potential for pharmaceutical and therapeutic applications.