Romanian Society of Pharmaceutical Sciences
 

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CONTROLLED RELEASE AND ANTIBACTERIAL EFFICACY OF TETRACYCLINE AND METRONIDAZOLE LOADED PCL NANOWIRES ON ZIRCONIUM SUBSTRATE

RAMONA-DANIELA RADU (DUȘMAN) 1, VALENTINA ANUȚA 2*, ROBERTA IRODIA 1, GEORGETA TOTEA 3, DOINA DRAGĂNESCU 4, IOANA DEMETRESCU 1,5

1 Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 313 Splaiul Independenței, 060042, Bucharest, Romania
2 Department of Physical and Colloidal Chemistry, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania
3 Buftea Obstetrics and Gynaecology Hospital, 070000, Ilfov, Romania
4 Department of Pharmaceutical Physics and Informatics, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania
5 Academy of Romanian Scientists, 3 Ilfov Street, 050044, Bucharest, Romania

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This study investigates the controlled release and antibacterial efficacy of tetracycline and metronidazole loaded on polycaprolactone (PCL) nanowires deposited on zirconium (Zr) substrate. The integration of PCL nanowires on Zr substrate offers a novel approach in enhancing the therapeutic effects of antibiotics, particularly against antibiotic-resistant strains. The PCL nanowires serve as an efficient drug delivery system, providing sustained and targeted release of the antibiotics, thereby maintaining therapeutic concentrations at the site of infection. The antibacterial activity of these nanowire-coated substrate was assessed against Escherichia coli and Staphylococcus aureus, demonstrating significant inhibition of bacterial growth. The study highlights the potential of this nanotechnology-based system in improving the efficacy of antimicrobial therapies, especially in the context of medical implants and wound healing.