Romanian Society of Pharmaceutical Sciences
 

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IN VIVO EVALUATION OF THE EFFECTS INDUCED BY HAWTHORN (CRATAEGI SP.) EXTRACT IN RATS, IN TWO EXPERIMENTAL DIET MODELS

ELENA IULIANA ILIE (IONIȚĂ) 1, OCTAVIAN TUDOREL OLARU 1, MARIA TEODORA PIȚURU 1,2, ANA CORINA POGAN 1, ELENA MOROȘAN 1, ANDREI VĂLEANU 1, ALEXANDRU RADU CORBU 3, ADRIANA ELENA NICA 4*, DANA ANTONIA ȚĂPOI 5, MARIA DANIELA TĂNĂSESCU 6,7, ALEXANDRU MINCĂ 6, CERASELA ELENA GÎRD 1

1Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
2 Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, 105 Splaiul Independentei Boulevard, 050097, Bucharest, Romania
3 Department of Horticulture & Food Science, University of Craiova, 13 AI Cuza Street, 200585, Craiova, Romania
4 Department of Anaesthesiology and Intensive Care, University Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
5 Department of Pathology, University Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
6 Department of Medical Semiology, Discipline of Internal Medicine I and Nephrology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
7 Department of Nephrology, Bucharest Emergency University Hospital, 169 Splaiul Independenței Street, 050098, Bucharest, Romania

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The present research aimed to evaluate the effects induced by hawthorn extract on biochemical parameters in two experimental diet models (hyperlipidic and hyperglucidic), correlated with cytotoxicity and embryotesting performed on Daphnia species, and histopathological evaluation of changes induced in the liver parenchyma. Research showed a dose-dependent variability of lethality (Daphnia bioassay) at a dose of 761.1 μg/mL at 48 hours, with D. pulex showing a higher sensitivity; the extract was shown to influence acceleration of embryogenesis with induction of certain morphological changes (elongation of the column of the appendix). On the biochemical constants in the experimental groups treated with hawthorn extract, an increase in HDL- cholesterol by 57.62 - 73.90%, a decrease in LDL-cholesterol by 9.51 - 11.43%, triglycerides by 3.16 - 12.12% was observed; the oligoelements analysed showed a statistically significant evolution for sodium in the hyperglucidic with hawthorn group, for a p-value of 0.0262, whereas for potassium, the group with hyperglucidic diet had a p-value of 0.0062.