Romanian Society of Pharmaceutical Sciences
 

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STUDY DESCRIBING THE FORMULATION AND THE RELEASE OF SOME ACTIVE PHARMACEUTICAL INGREDIENTS FROM HPMC HYDROPHILIC MATRIX TABLETS. NOTE I

GABRIEL ȘARAMET 1#, FLAVIAN ȘTEFAN RĂDULESCU 2#, DALIA SIMONA MIRON 3#, ȘTEFANIA-FELICIA BĂRBUCEANU 4#, ANA ANDREEA STĂNESCU 1#*, LAVINIA VLAIA 5#, SILVIU PIȚURU 6#, DUMITRU LUPULIASA 1#

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Bucharest, Romania
2 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Drug Industry and Pharmaceutical Biotechnologies, Bucharest, Romania
3 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Physics and Informatics, Bucharest, Romania
4 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, Bucharest, Romania
5 .“Victor Babeș” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, Timișoara, Romania
6 .“Carol Davila” University of Medicine and Pharmacy Bucharest, 37th Dionisie Lupu Street, 020022, Bucharest, Romania

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For this study, hydroxypropylmethylcellulose (HPMC) matrix tablets were prepared by direct compression containing active pharmaceutical ingredients (APIs) from different biopharmaceutical classification system (BCS) classes, diclofenacum sodium (DicloNa) and phenytoin sodium (PheNa). For each API, three formulations were obtained, varying the amount of API and the concentration of HPMC matrix. After preparation, the tablets were submitted to pharmaco-technical tests and dissolution tests. The dissolution data was then fitted on different release models. Informations about the release kinetics from our tablets were obtained from these fittings.