Romanian Society of Pharmaceutical Sciences
 

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DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS

IMREN ESENTÜRK-GÜZEL 1,2# , EVREN ALGIN YAPAR3# , SIMONA CAVALU 4*, İBRAHIM TUĞKAN ŞEKER5 , EBRAR İNAL 6,7, MURAT KARTAL 6,8 , RABIA ÇAKIR2,9, RABIA YILMAZ ÖZTÜRK 2.9, FERIHA GÖKSU 10, SIBEL BÖLEK 10, AYYÜCE TÜRKMEN 1

1Department of Pharmaceutical Technology, Hamidiye Faculty of Pharmacy, University of Health Sciences, Istanbul, Türkiye
2 Türkiye Biotechnology Institute, Health Institutes of Türkiye (TUSEB), Istanbul, Türkiye
3 Department of Pharmaceutical Technology, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Türkiye
4 Department of Preclinical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Bihor, Romania
5 Department of Gastronomy and Culinary Arts, School of Tourism and Hotel Management, Sivas Cumhuriyet University, Sivas, Türkiye 6Department of Pharmacognosy, Faculty of Pharmacy, Bezmialem Vakıf University, Istanbul, Türkiye
7 Institute of Health Sciences, Bezmialem Vakıf University, Department of Pharmacognosy and Natural Product Chemistry, Istanbul, Türkiye. 8Phytotheraphy Research Center, Bezmialem Vakıf University, Istanbul, Türkiye
9 Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Istanbul, Türkiye 10Department of Food Technology, Experimental Medicine Research and Application Centre, University of Health Sciences, Istanbul, Türkiye

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The aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2 - 268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.