Romanian Society of Pharmaceutical Sciences
 

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PHARMACOLOGICAL EVALUATION OF RHODIOLA ROSEA L. EXTRACT FROM THE KAZAKH ECOSYSTEM: IMPLICATIONS FOR OBESITY MANAGEMENT IN MALE RATS

МOLDIR ZHUMAGUL 1,2,3*, MILENA RAŠETA 4 , JOVANA MIŠKOVIĆ5 , ANAR B. MYRZAGALIYEVA 3 , MERUYERT KURMANBAYEVA 1 , YUSUFJON GAFFOROV 6,7,8, SERIK A. KUBENTAYEV 2 , TATYANA KOBYLINA 1,9, RAUSHAN SHAIKHYMBEKOVA 10, ADIL KUSMANGAZINOV 1

1Al-Farabi Kazakh National University, Al-Farabi Avenue, 71/19, 050060, Almaty, Kazakhstan
2 “Astana Botanical Garden” Branch of the Republican State Enterprise on the Right of Economic Management “Institute of Botany and Phytoinroduction”, Orynbor 16, 010016, Astana, Kazakhstan
3 Astana International University, Qabanbay Batyr Ave 8, 020000, Astana, Kazakhstan
4 Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia
5 Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 2, 21000 Novi Sad, Serbia
6 Central Asian Centre for Development Studies, New Uzbekistan University, 54 Mustaqillik Avenue, Tashkent, 100007, Uzbekistan 7Department of Education and Training Management, Tashkent International University of Education, Imam Bukhari Street, Tuzel-2 block, Tashkent, 100207, Uzbekistan
8 Institute of Botany, Academy of Sciences of Republic of Uzbekistan, 32 Durmon Yuli, Tashkent 100125, Uzbekistan
9 Institute of Genetic and Physiology, prospect Al-Farabi, 93, Bostandyk district, 050060/A15E3K2, Almaty, Kazakhstan
10 Asfendiyarov Kazakh National Medical University, Tole by 94, 050012, Almaty, Kazakhstan

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The aim of the study was to conduct a comprehensive assessment of the pharmacotherapeutic effect of the extract R. rosea in obesity including GC-MS analysis, biochemical analysis of blood serum and open field test were also conducted. The purebred 3-month-old white male laboratory rats were divided into three groups, control and two experimental groups with alimentary obesity with and without R. rosea treatment and fed with a low-calorie diet. Body weight decreased significantly with concomitant administration of R. rosea extract in the third group, whereas active weight loss was observed from 263.39 ± 10.80 g on day 25 to 213.34 ± 8.74 g on day 30. Treatment with R. rosea extract reduced total body weight, abdominal fat mass, and lipids. The character of the pathological process was established in the rats with obesity after the application of R. rosea normalized the rats' liver enzyme levels. The open field test showed that the rats treated with R. rosea extract had a pronounced resistance of the nervous system and a moderate level of autonomic and emotional behaviour. The obtained results suggest that R. rosea extract should be used against obesity due to its anti-adipogenic properties.