Romanian Society of Pharmaceutical Sciences
 

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COMPARATIVE IN VITRO DRUG RELEASE EVALUATIONS OF NEW HYDROGELS CONTAINING OXICAMS

FLAVIAN ȘTEFAN RĂDULESCU1, DALIA SIMONA MIRON2, DOINA DRĂGĂNESCU2*, SILVIA MARIA STOICESCU3, ANA ANDREEA STĂNESCU4, ADRIAN COSMIN ROȘCA5

University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6th Traian Vuia Street, 020956, Bucharest, Romania
1 .Department of Drug Industry and Pharmaceutical Biotechnologies
2 .Department of Pharmaceutical Physics and Informatics
3 .Department of Obstetrics and Gynecology, Polizu Clinical Hospital, Faculty of Medicine
4 .Department of Pharmaceutical Technology and Biopharmaceutics
5 .Ovidius University Constanta, Faculty of Pharmacy, Department of Drug Analysis

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The paper presents the results of in vitro release and rheological evaluations performed on 12 experimental semisolid dosage forms containing oxicams as active pharmaceutical ingredient dispersed in hydrophilic matrix. Non-ionic tensioactive agents were added as both solubility-increasing excipients and absorption promoters. The in vitro release data obtained on a static vertical diffusion cell system was fitted with two kinetic models, square root law and first order kinetic models. The results were further analysed in relation with the rheological parameters and underline the critical role of correlated structural and release evaluations in the selection of optimal formulation candidate, during the research and development phase.