Romanian Society of Pharmaceutical Sciences
 

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ORDERED MESOPOROUS CARBON BASED SENSOR FOR SENSITIVE DETECTION OF VITAMIN B6 IN PHARMACEUTICALS

IRINA MIRELA APETREI1, CONSTANTIN APETREI2*, OLIMPIA DUMITRIU BUZIA1

1.Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, Romania
2 .Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, Romania

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A novel screen-printed sensor based on ordered mesoporous carbon was used for the electrochemically determination of pyridoxine (vitamin B6) in pharmaceuticals. Various experimental parameters were studied and optimized such as the nature and the pH of the electrolyte solution, the scanning rate and the interference of different chemical species. Optimal electroanalytical conditions are represented by: phosphate buffer (pH 7.0) with the concentration of 0.01 mol/L and the potential scanning rate of 0.1 V/s. In these conditions, interferences of the main compounds found in pharmaceuticals were less than 1%. The linearity range of the sensor in order to determine the concentration of pyridoxine was from 1 to 200 μM with a detection limit of 0.42 μM. Voltammetry was successfully applied for the quantification of vitamin B6 in pharmaceuticals. The results obtained for the ordered mesoporous carbon-based sensor were compared to those obtained by the standard spectrophotometric method resulting a very good correlation.