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VITIS VINIFERA L. AND SAMBUCUS NIGRA L. EXTRACTS ATTENUATE OXIDATIVE STRESS AND INFLAMMATION IN FEMORAL ISCHEMIA

CRISTINA BIDIAN 1, DANIELA-RODICA MITREA 1*, CORINA TATOMIR 2, MARIA PERDE-SCHREPLER 2, CAMELIA LAZĂR 3, IOANA CHEȚAN 1, POMPEI BOLFA 4,5, LUMINIȚA DAVID 6, SIMONA CLICHICI 1, GABRIELA ADRIANA FILIP 1, MARIANA MUREȘAN 7, OTILIA MICLE 7

1.Department of Physiology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006, ClujNapoca, Romania
2.Department of Radiobiology and Tumour Biology, “Ion Chiricuță” Oncology Institute, 34-36 Republicii Street, 400015,
Cluj-Napoca, Romania
3.Department of Morphopathology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania
4.University of Agricultural Sciences and Veterinary Medicine, Department of Pathology, Cluj-Napoca, Romania
5.Ross University School of Veterinary Medicine, Department of Biomedical Sciences, Basseterre, St. Kitts, West Indies
6.Faculty of Chemistry and Chemical Engineering “Babeş-Bolyai” University, 11 Arany Janos Street, 400028, Cluj-Napoca,
Romania
7.Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 10 Piața 1 Decembrie
Street, 410073 Oradea, Romania

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Ischemia is a major cause of cardiovascular diseases, with an increased rate of morbidity and mortality, pathogenetically characterized by redox imbalance, inflammation and tissue damage. The aim of this study was to investigate the effects of grape seeds (Vitis vinifera L.) and elderberry fruit (Sambucus nigra L.) extracts on the gastrocnemius muscle lesions induced by the experimental femoral ischemia. The total polyphenolic content and the antioxidant activity of the two extracts were also evaluated. The effects of ischemia-reperfusion damage were investigated by quantification of oxidative stress, inflammation, matrix metalloproteinases-2 activity and histopathological analysis of the gastrocnemius muscle. Both extracts showed beneficial antioxidant effects, decreasing the lipid peroxidation in muscle homogenates. The administration of Vitis vinifera L. extract diminished the metalloproteinase-2 activity while the treatment with Sambucus nigra L. extract exerted potent antiinflammatory effects.