« Back to Farmacia Journal 1/2023

UNEXPECTED BEHAVIOR OF TRISILANOLISOBUTYL-POSS, KEY COMPOUND IN DRUG DELIVERY SYSTEMS, DURING MASS SPECTROMETRY ANALYSIS

CAROLINA COJOCARIU 1,4#, NICULINA DANIELA HĂDADE 2#, MIHAI COSMIN PASCARIU 1,3, CALIN LADASIU 3, ALINA SERB 4*, EUGEN SISU 4, MARIUS GEORGESCU 5

1”Vasile Goldiș” Western University of Arad, 86 Liviu Rebreanu Street, 310414, Arad, Romania
2“Babeş-Bolyai” University, Faculty of Chemistry and Chemical Engineering, Supramolecular Organic and Organometallic
Chemistry Centre, 11 Arany Janos Street, 400028, Cluj-Napoca, Romania
3Renewable Energy and Electrochemistry Department, National Institute of R&D for Electrochemistry and Condensed
Matter - INCEMC, 144 Aurel Păunescu-Podeanu Street, 300569, Timișoara, Romania
4“Victor Babeș” University of Medicine and Pharmacy, Faculty of Medicine, Biochemistry and Pharmacology Department,
Biochemistry Discipline, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
5“Victor Babeș” University of Medicine and Pharmacy, Faculty of Medicine, Function Sciences Department, Physiology Discipline, 2 Eftimie Murgu Square, 300041, Timișoara, Romania

Download Full Article PDF

The structural investigation of trisilanolisobutyl-POSS, an important precursor for biocompatible materials and drug delivery systems, was performed by (+) ESI-OT-mass spectrometry, using multiple-stage fragmentation. This allowed us to obtain a series of MS1 - MS10 spectra, which are the first to be reported in the field of organosilicon chemistry and pharmaceutical additives. The structure of the fragmentation ions was fully assigned.