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TWO NEW SANDWICH-TYPE COMPOUNDS BASED ON {AsW9} WITH Pd2+ AND Pt4+ CATIONS – SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY

LAVINIA BERȚA (GRAMA)1, FRANCISC BODA1*, GHEORGHE BORODI2, AURA RUSU3, HAJNAL KELEMEN3, ADRIAN MAN4, ANCA MARE4, ȘERBAN-ANDREI GÂZ-FLOREA5

1.General and Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy, 38 Gh. Marinescu Street, 540139, Târgu Mureş, Romania
2.National Institute of R&D of Isotopic and Molecular Technologies, 65-103 Donath Street, 400293, Cluj-Napoca, Romania
3.Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy, 38 Gh. Marinescu Street, Târgu Mureş, Romania
4.Microbiology Department, Faculty of Medicine, University of Medicine and Pharmacy, 38 Gh. Marinescu Street, 540139, Târgu Mureş, Romania
5.Organic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy, 38 Gh. Marinescu Street, 540139, Târgu Mureş, Romania

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Following methods described in the literature, two new complexes of [AsW9O33]9- ligand (AsW9) were synthesized with Pd2+ and Pt4+ cations: Na12[(AsW9O33)2Pd3]*24H2O (AsW9Pd); Na6[(AsW9O33)2Pt3]*46H2O (AsW9Pt). The complexes were obtained by direct addition of cation salt solution (PdCl2/K2PtCl6) to AsW9 sodium salt solution at pH = 8.5, keeping the temperature between 70 - 80ºC. After physico-chemical characterization (UV, IR, TGA, conductometry, X-ray), the complexes have been associated to Hervè structures which consist of two AsW9 units connected by O-Pd/Pt-O bridges. Their biological activity was studied in vitro on Gram positive (Staphylococcus aureus ATCC 29213) and Gram negative (Escherichia coli ATCC 25922) bacterial strains, and showed significant antibacterial activity, inhibiting both E. coli and S. aureus, with better effect on the Gram negative strain.