Romanian Society of Pharmaceutical Sciences
 

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THERMAL BEHAVIOUR OF SOME PHARMACEUTICAL PRODUCTS CONTAINING IRBESARTAN, COMPARING TO THE ACTIVE SUBSTANCE

IOANA CRISTINA TIȚA 1, ELEONORA MARIAN 2, BOGDAN TIȚA 3*, CLAUDIA CRINA TOMA 3, FELICIA GLIGOR 4, LAURA VICAȘ 1,2, EMMA ADRIANA OZON 1

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.University of Oradea, Faculty of Medicine and Pharmacy, Speciality of Pharmacy, 29 Nicolae Jiga Street, 410028, Oradea, Romania
3.“Vasile Goldiș” Western University of Arad, Faculty of Pharmacy, Department of Pharmaceutical Sciences, 86 L. Rebreanu Street, 300041, Arad, Romania
4.“Lucian Blaga” University of Sibiu, 2A Lucian Blaga Street, 550169, Sibiu, Romania

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Thermal analysis is one of the most widely used methods for studying the solid state of pharmaceutical substances. This work reports the study of the thermal behaviour of irbesartan active substance and pharmaceutical products, together with the determination of the melting points by TG, DTG and DSC. The Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffractometry (XRPD) were used as complementary techniques. It was observed that the commercial samples showed a different thermal profile than the active substance caused by the presence of excipients and to possible interactions of these with the active substance.