Romanian Society of Pharmaceutical Sciences

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THE THERAPEUTIC EFFECT OF CHANGYUNING GRANULES COMBINED WITH RETENTION ENEMA ON ALLEVIATING THE SYMPTOMS OF ULCERATIVE COLITIS

YUNLANG NA 1, JINKUN ZHAO 1, ZHENYU SU 1, YAN JIAO 2*

1Harbin Hospital of Traditional Chinese Medicine, Harbin, 150000, China
2The People's Hospital of Dazu, Chongqing, 402360, China

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Ulcerative colitis (UC) is an inflammatory bowel disease that lacks an effective treatment without severe side effects. In this study, we aimed to evaluate the clinical efficacy of Changyuning granules (CYNG) combined with retention enema on patients with ulcerative colitis (UC) evaluating the effects on the intestinal mucosa of patients. Ninety-six patients with UC were randomly divided into observation group and control group (48 cases in each group). Patients in the control group were treated for 12 weeks with Kuiyangling enema, and the observation group was treated with CYNG plus Kuiyangling enema. Both types of treatment can improve the main clinical symptoms such as diarrhoea, bloody purulent stool, abdominal pain, the effects being superior after CYNG treatment. The total effective rate of the observation group is higher than that of the control group. The treatment with CYNG plus Kuiyangling enema is superior to the treatment with Kuiyangling enema in reducing intestinal mucosal lesions, inhibiting the expression of TLR4, reducing inflammation, promoting the recovery of intestinal mucosal function, and improving the immune function of patients. In conclusion, CYNG combined with Kuiyangling enema has a good clinical effect in the treatment of UC, which can significantly improve intestinal mucosal inflammation, promote the recovery of intestinal mucosal function, and improve the immune function of patients with minimum side effects.