Romanian Society of Pharmaceutical Sciences

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THE PROTECTIVE ROLE OF MALVIDIN ON THE HEMATOLOGICAL, BIOCHEMICAL AND HISTOPATHOLOGICAL PARAMETERS OF MARSH FROG (Pelophylax ridibundus) EXPOSED TO SUBLETHAL DOSES OF ROUNDUP®

PĂUNESCU ALINA1,2, DIMA ROMULUS2, PONEPAL MARIA CRISTINA3, BRINZEA GHEORGHITA3, IOSUB ION3, SOARE LILIANA CRISTINA3, DOINA DRĂGĂNESCU4*, CRISTINA DINU-PIRVU4

1University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3 Mănăştur Str., Cluj-Napoca, Romania
2University Politechnica of Bucharest, 313 Splaiul Independenţei Str., Bucharest Romania
3University of Piteşti, Faculty of Science, Department of Ecology, 2 Targu din Vale Str., Piteşti, Romania
4Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, 6 Traian Vuia Str., Romania

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In the present paper it was investigated the protective effect of malvidin on the hematological, biochemical and histopathological parameters of marsh frog (Pelophylax ridibundus) exposed to sublethal concentration of Roundup® herbicide. The animals were divided in 3 experimental groups: lot of control individuals, second lot containing animals which were subjected to Roundup® in a dose of 0.138mL/L administered in water for 3 weeks and third lot containing animals which were subjected to malvidin in a dose of 1mg/kg body weight administered by intraperitoneal injections and kept in water with the same concentration of Roundup®. Exposure of Pelophylax ridibundus adults to Roundup® herbicide action has the effect of installation of pathological changes in the liver tissues characterized by vacuolation of hepatocytes and nuclear pycnosis, perisinusoidal fibrosis, dilatation of Disse space and sinusoid capillaries, presence of cellular infiltrates. We also observed increasing the hepatosomatic index, the number of white blood cells (WBC), serum cholesterol and triglycerides values, and decreasing the number of red blood cells (RBC) and glycaemia values. Malvidin administration as an adjunct, counteracts the toxic action, describing itself as normal liver parenchyma in animals intoxicated with Roundup® herbicide, without lesion, and a return to normal values of the studied markers.