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THE PREVALENCE OF POTENTIAL DRUGDRUG INTERACTIONS IN THE THERAPY OF ROMANIAN COMMUNITY PHARMACY’S PATIENTS

CAMELIA DENISA BUCSA^*, IRINA CAZACU, ANDREEA MARIA FARCAS, MARIUS BOJIȚĂ

Drug Information Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Romania

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Drug-drug interactions (DDIs) are a concern for patients and providers, as multiple medication use is becoming more common to manage complex diseases. However, a high prevalence of potential drug-drug interactions (pDDIs) can lead to a higher probability to develop an adverse drug reaction (ADR) or suboptimal therapeutic effects. The objective of our study was to measure the frequency, nature and severity of the potential DDIs in prescriptions from a Romanian community pharmacy. We analysed 308 prescriptions (all reimbursed prescriptions from one month) of 243 patients for the detection of the pDDIs. Our study showed that potential drug-drug interactions are highly prevalent (34.42% of prescriptions with at least one DDI) in patients’ therapy and the modernization of prescribing and dispensing medicines is necessary.