Romanian Society of Pharmaceutical Sciences
 

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THE PHYTOBIOLOGICAL TESTING OF SOME NEW THIOUREA DERIVATIVES

CARMELLINA DANIELA BĂDICEANU1*, NICOLETA DIMCEVICI POESINA2, ALEXANDRU VASILE MISSIR1, CAMELIA ELENA STECOZA1, MIHAELA DINU3

„Carol Davila” University of Medicine and Pharmacy, Traian Vuia 6, sect. 2, 020956, Bucharest, Romania, Faculty of Pharmacy
1 .Pharmaceutical Chemistry Department
2 .Applied Mathematics and Biostatistics Department
3 .Pharmaceutical Botany and Cell Biology Department

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Many thioureas, some of therapeutic use, have plant-growth inhibitory activity, therefore we have considered useful the phytobiological testing of some new compounds having thiourea scaffold, synthesized from 2-thiophenecarboxylic, 3-thiophenecarboxylic and 2-thiopheneacetic acids, using Constantinescu method, Triticum test. It has been shown that the effect on mitosis, of the nine tested compounds, is directly proportional to the concentration of solutions and does not depend substantially on the nature and position of the substitutes on the aromatic ring. It was found also, that the most pronounced inhibitory effect was for 2-thiopheneacetic acid thioureas and the effect is decreasing in intensity for 3-thiophenecarboxilic and 2-thiophenecarboxilic derivatives.