Romanian Society of Pharmaceutical Sciences
 

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THE LEVELS OF SERUM BIOMARKERS OF INFLAMMATION IN HEMODIALYSIS PATIENTS

ANGELA ANTONESCU1, SIMONA IOANA VICAS2*, ALIN C. TEUSDEA2, IOANA RATIU3, INA ANDREEA ANTONESCU4, OTILIA MICLE1, LAURA VICAS6, MARIANA MURESAN1, FELICIA GLIGOR5

1.University of Oradea, Faculty of Medicine and Pharmacy Oradea, Department of Preclinical Disciplines, Oradea, Romania
2.University of Oradea, Faculty of Environmental Protection, Oradea, Romania
3.University of Oradea, Faculty of Medicine and Pharmacy Oradea, Department of Internal Medicine, Oradea, Romania
4.County Clinical Emergency Hospital Oradea, Romania
5.University “Lucian Blaga”, Sibiu, Faculty of Medicine and Pharmacy Oradea, Department of Pharmacy
6.University of Oradea, Faculty of Medicine and Pharmacy Oradea, Department of Pharmacy, Oradea, Romania

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Leptin controls metabolism, energy balance and can also intensify inflammation by inducing mononuclear cell activation and proliferation. It realizes this last effect by stimulating the production of pro-inflammatory cytokines such as interleukine-6 (IL-6), tumour necrosis factor α (TNF-α), interleukine-8 (IL-8). The objective of the present study was to investigate the serum levels of IL-6, IL-8 and TNF-α and leptin in chronic renal failure patients submitted to haemodialysis. In this study there were included two groups of subjects, one of them being chronic renal failure patients submitted to haemodialysis (n=60) and the other group was represented by healthy volunteers (n=30). Serum levels of inflammatory cytokines (IL-6, IL-8, TNF-α) and leptin were assessed before and after haemodialysis. Leptin levels (9.609 ± 6.775 ng/mL) were high in haemodialysis patients if compared to the control group (4.585 ± 1.302 ng/mL) and after dialysis the concentration has decreased (6.466 ± 4.008 ng/mL). The concentrations of TNF-α (25.280 ± 4.640 pg/mL), IL-6 (8.073 ± 4.608 pg/mL) and IL-8 (34.370± 9.104 pg/mL) were high in patients submitted to haemodialysis in comparison with the group of healthy volunteers TNF-α (6.877 ± 1.447 pg/mL), IL-6 (2.014 ± 0.046 pg/mL), IL-8 (18.090 ± 5.840 pg/mL). Haemodialysis patients showed elevated levels of leptin, IL-6, IL-8 and TNF-α. After dialysis it was observed a significant decrease of leptin level (p = 0.0091), whereas IL-8 increased significantly (p < 0.0001).