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THE INTERRELATIONSHIP BETWEEN THE DRUG EMBEDDED TIZR SURFACE PROPERTIES AND ANTIBACTERIAL EFFECT

MANUELA ELENA VOICU 1, DOINA DRĂGĂNESCU 2*, VALENTINA ANUȚA 3, ANDREI BOGDAN STOIAN 1, DANIELA IONIȚĂ 1, IOANA DEMETRESCU 1,4

1Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 313 Splaiul Independenței, 060042, Bucharest, Romania
2Department of Pharmaceutical Physics and Informatics, “Carol Davila” University of Medicine and Pharmacy, 020956,
Bucharest, Romania
3Department of Physical and Colloidal Chemistry, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania
4Academy of Romanian Scientists, 3 Ilfov Street, 050044, Bucharest, Romania

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This paper is a report about the elaboration of surfaces coated with PLA nanofibers embedded with gentamicin and its release. The manuscript investigated surface analysis, drug loading and the kinetics of the release. The research design includes FT-IR structural identification of embedded gentamicin, Scanning Electronic Microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) for morphology and composition and Atomic Force Microscopy (AFM) to measure adhesion force. The antibacterial inhibition index was evaluated against a positive and a negative Gram bacteria such as Staphylococcus aureus and Escherichia coli, respectively. As a conclusion of above determinations positive effect of drug was evidenced and discussed.