Romanian Society of Pharmaceutical Sciences

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THE IMPORTANCE OF SYMPTOMATOLOGY IN NON-ADHERENCE OF PATIENTS WITH OBSTRUCTIVE SLEEP APNOEA SYNDROME TO CONTINUOUS POSITIVE AIRWAY PRESSURE THERAPY

ROMICA BURCEA 1,2*, FLORIN DUMITRU MIHALTAN 2,3

¹Rosiori de Vede Pneumology Hospital, Rosiori de Vede, Romania
²“Carol Davila” University of Medicine and Pharmacy Bucharest, Romania
3“Marius Nasta” Pneumology Institute Bucharest, Romania

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Obstructive sleep apnoea syndrome (OSAS) is a lesser-known pathology in Romania. Continuous positive airway pressure therapy (CPAP) is the gold standard for treating OSAS. The study's main objective was to investigate how adherence to therapy influences the evolution of OSAS. We conducted a prospective, observational, non-randomized study on an essay of 380 observations with 95 observational units (95 patients who were diagnosed with OSA, part of the tracked variables being measured at 4-time points: I-moment of diagnosis, II-1 month, III-6 months, IV-12 months). There are differences in statistical significance for Epworth scores measured at different points in time. Associated with the Epworth score, the following predictive factors had influences with statistical significance: the presence of air humidifier, systolic blood pressure, diastolic blood pressure, heart rate, Mallampati score, type of CPAP, type of CPAP mask, level of CPAP pressure. Many factors can influence the adherence of patients with OSAS to CPAP therapy. The level of daytime sleepiness can be an important predictor of adherence to therapy.