THE EFFICIENCY OF HYALURONIC ACID IN THE MANAGEMENT OF RADIATION INDUCED CYSTITIS
RADU DRAGOS MARCU 1,2, ARSENIE DAN SPINU 1,2*, DAN LIVIU DOREL MISCHIANU 1,2,3, IOANA SORINA OPREA 4, CAMELIA CRISTINA DIACONU 2,5, BOGDAN SOCEA 2,6, OVIDIU GABRIEL BRATU 1,2,3
1.Clinic of Urology, “Dr. Carol Davila” University Emergency Central Military Hospital, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3.Academy of Romanian Scientists, Bucharest, Romania
4.Intensive Care Unit, “Dr. Carol Davila” University Emergency Central Military Hospital, Bucharest, Romania
5.Department of Internal Medicine, Emergency Clinical Hospital, Bucharest, Romania
6.Surgery Department, “Sf. Pantelimon” Emergency Hospital, Bucharest, Romania
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Radiation cystitis is a complex pathology, with a significant negative impact on the patient’s quality of life, often proving to be a real challenge for physicians due to its bothersome symptoms and severe complications such as recurrent haematuria. The mechanism involved in radiation induced cystitis pathogenesis is the injury of the bladder’s urothelium and its glycosaminoglycans layer. We have analysed the current data in terms of radiation induced cystitis and the role of the glycosaminoglycans replenishment therapy with hyaluronic acid in the management of radiation cystitis. The efficiency of hyaluronic acid in the management of radiation cystitis has been evaluated by a small number of clinical trials, but all of them have provided good results in terms of safety, as well as in improving the urinary symptoms and the patient’s quality of life.