Romanian Society of Pharmaceutical Sciences

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THE EFFECT OF SOMATOSTATIN COMBINED WITH OMEPRAZOLE ON PATIENTS WITH SEVERE ACUTE PANCREATITIS

JIANHUA HONG 1#, JINYAN MI 2#*

1Department of Digestive Internal Medicine, Tonglu First people's Hospital, Tonglu, Hangzhou, 311500, China
2Orthopedic Aftercare Comprehensive Ward, Tonglu Hospital of Traditional Chinese Medicine, Tonglu, Hangzhou, 311500, China

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This study aimed to investigate the effects of somatostatin (SST) combined with omeprazole (OMZ) on patients with severe acute pancreatitis (SAP). Ninety-eight SAP patients were randomly divided into two groups (control group and experimental group). The control group received conventional SAP treatment, and the experimental group received conventional and SSTOMZ treatment for two weeks. The differences in serum levels of various indicators and biomarkers between the two groups on admission and after two weeks of treatment were compared. The results showed that after two weeks of treatment, in the experimental group the systemic inflammation and oxidative stress were inhibited, protecting the intestinal mucosal barrier function and regulating the gastrointestinal hormones and improve the therapeutic effect of standard SAP treatment with a decrease in the occurrence of adverse reactions.