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THE ASSAY OF FELODIPINE BY SECOND DERIVATIVE SPECTROPHOTOMETRY

ALEXANDRA FILARETA NEAGU, IOANA CLEMENTINA CONSTANTINESCU^*, ANGELA NEDELCU

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The present paper aimed the development of a new felodipine assay method, a calcium channel antagonists, used as an antihypertensive drug. The second derivative of the felodipine absorption spectra was used at wavelengths between 239 - 230 nm, in methanolic solution. It was established the concentration range for Beer`s law. It was assessed that there is a linear relationship between the second derivative and the concentration of the felodipine solutions, in the range between 1.946·10-6 and 19.46·10-6 g/mL. The correlation coefficient and the regression equation were found to be r = 0.99975 and y = 0.00883x + 0.00487. This method proved to be sensitive, reproducible and accurate.