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SYNTHESIS OF NEW UNSYMMETRICAL 1,4- DIHYDROPYRIDINE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS

LAURENŢIU MORUŞCIAG¹, CONSTANTIN DRĂGHICI², GEORGE MIHAI NIŢULESCU^1*

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The 1,4-dihydropyridine structure is a very versatile and drug feasible template allowing multiple structural modulations and the resulted molecules can exert potent and selective actions on a large spectrum of biological targets. As a continuation of our previous research focused on the 1,4-dihydropyridine scaffold we designed and synthesized some new methyl 5-alkyl/aryl-carbamoyl-2,6-dimethyl-4-(substituted-phenyl)-1,4-dihydro pyridine-3-carboxylate derivatives. The obtained compounds were characterized by elemental, IR and NMR analyses and are proposed for antitumor evaluation.