Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS, CHARACTERIZATION AND IN VITRO BIOLOGICAL STUDIES OF NOVEL SCHIFF BASE AND ITS TRANSITION METAL COMPLEXES DERIVED FROM SULPHADOXINE

AMINA MUMTAZ 1,2,3*, TARIQ MAHMUD 2, M.R.J. ELSEGOOD 3, G.W. WEAVER 4, JAVED IQBAL QAZI 4, FARAH DEEBA 4

1.PCSIR Laboratories complex, Ferozepur Road, Lahore, Pakistan
2.Institute of Chemistry, University of Punjab, Lahore 54590, Pakistan
3.Departemnt of Chemistry, Loughborough University, Loughborough LE11 3TU, England, UK
4.Department of Zoology, University of Punjab, Lahore, 54590, Pakistan

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The new series of coordination transition metal complexes were preparedfrom Schiff base obtained from sulphadoxineandthiophene-2-carboxaldehyde. The structural investigation of Schiff base and their complexes were characterized by different instrumental procedures like microanalysis, spectroscopic andthermogravimetric examination. The integrated Schiff base ligand and transition metal complexes were subjected to antibacterial and antifungal activities.The studies demonstrated the enhanced activity of metal complexes against reported microbeswhen compared with free ligand.