Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF NEW DIPHENYL SULFONE DERIVATIVES

THEODORA-VENERA APOSTOL 1*, CONSTANTIN DRĂGHICI 2, LAURA-ILEANA SOCEA 1,
OCTAVIAN TUDOREL OLARU 3, GABRIEL ȘARAMET 4, CRISTIAN ENACHE-PREOTEASA 5,
ȘTEFANIA-FELICIA BĂRBUCEANU 1

1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Organic Chemistry Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
2“Costin D. Nenițescu” Institute of Organic Chemistry, Romanian Academy, 202B Splaiul Independenței Street, 060023,
Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Botany and Cell Biology
Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
4“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Technology and
Biopharmacy Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
5National Phytosanitary Laboratory, 11 Voluntari Boulevard, 077190, Voluntari, Ilfov, Romania

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Taking into account that the substituted diphenyl sulfone is an important pharmacophore in medicinal chemistry, in this paper, we report the synthesis, characterization, and cytotoxicity evaluation of seven new compounds: six ethyl 1,3-oxazol-5yl carbonates and an acyclic product (ethyl ester of an N-acyl-α-amino acid), containing the arylsulfonylphenyl moiety. The synthesized compounds were characterized by elemental analysis and spectral techniques (UV-Vis, FT-IR, MS, 1H-NMR, 13C-NMR). Their purity was checked by reversed phase HPLC. The cytotoxic effect of new compounds was assessed using Daphnia magna bioassay.