Romanian Society of Pharmaceutical Sciences

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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY EVALUATION OF NEW AGENTS FROM BENZAMIDES CLASS

DIANA CAMELIA NUŢĂ1*, MARIANA CARMEN CHIFIRIUC2, CONSTANTIN DRĂGHICI3, CARMEN LIMBAN1, ALEXANDRU VASILE MISSIR1, LAURENŢIU MORUŞCIAG1

1University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2University of Bucharest, Faculty of Biology, Microbiology-Immunology Department, 1-4 Ale. Portocalelor, Bucharest 60101, Romania
3The Organic Chemistry Center of Romanian Academy “C. D. Neniţescu”, Splaiul Independenţei 202B, Bucharest, Romania

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The use of most antimicrobial agents is limited, not only by the rapid developement of drug resistance, but also by the unsatisfactory status of present treatment of bacterial infections and drug side effects. This paper is a continuation of our research performed in order to develop new fluoro-trifluoromethyl-substituted benzamides with an improved antimicrobial profile, which targets the ideal antiseptic characteristics. These new fluoro-trifluoromethyl-substituted N- (2 - diethylaminoethyl) - N - (2,6 - dimethylphenyl) - benzamides (hydrochlorides) were characterized in terms of spectral and antimicrobial action, presenting a broad spectrum of action that was correlated with molecular substitution.