Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS, BIOEVALUATION AND MOLECULAR PROPERTIES OF SOME TRIAZINE DERIVATIVES

GABRIELA TATARINGA1, ANA-MARIA ZBANCIOC1, ALEXANDRA JITAREANU1, CRISTINA TUCHILUS2*, CORNELIA MIRCEA3

1University of Medicine and Pharmacy “Grigore T.Popa” Iasi, Romania, Faculty of Pharmacy, Department of Organic Chemistry
2University of Medicine and Pharmacy “Grigore T.Popa” Iasi, Romania, Faculty of Pharmacy, Department of Microbiology
3University of Medicine and Pharmacy “Grigore T.Popa” Iasi, Romania, Faculty of Pharmacy, Department of Biochemistry

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A series of 1,2,4-triazines have been synthesized and characterized by means of TLC, melting point, IR spectral data and elemental analysis. The synthesized compounds were screened for their antibacterial activity against Gram positive and Gram negative bacteria and Candida sp. Screening of antioxidative capacity was based on ability to scavenge free radicals by DPPH (2,2-diphenyl-1-picryl-hydrazyl) method and by reducing ability. Both antimicrobial and antioxidant activities depended on some structural characteristics of the synthesized compounds. The compounds II and III were subjected to molecular properties prediction, lipophilicity.