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SYNTHESIS AND CHARACTERIZATION OF NEW ACYL-OXIMINES DERIVATIVES WITH POTENTIAL PHARMACOLOGICAL ACTIVITY

DANA MIHAELA CIOROIANU¹, LAUREȚIU MORUȘCIAG^1*, MIRON TEODOR CĂPROIU², CARMEN LIMBAN¹, ILEANA CORNELIA CHIRIȚĂ¹, DIANA CAMELIA NUȚĂ¹

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2The Organic Chemistry Center of Romanian Academy “C.D. Nenițescu”, Splaiul Independenței 202B, Bucharest, Romania

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In our previous article we presented the synthesis and characterization of nine new acyl-oximines derivatives. We continued our research in order to synthesis new bioactive molecules with tricyclic structures which might become new compounds with pharmacological properties similar with the tricyclic antidepressants. These new substances are O-acyl-oximine derivatives with 10,11-dihydro-5H-dibenzo[a,d]cycloheptadienic and O-acyl-oximine drivatives with 5H-dibenzo[a,d]cycloheptatrienic structure. The structures of these new compounds were confirmed by elemental analysis, infrared and NMR spectra.

« Back to Farmacia Journal 3/2013

SYNTHESIS AND CHARACTERIZATION OF NEW ACYL-OXIMINES DERIVATIVES WITH POTENTIAL PHARMACOLOGICAL ACTIVITY

DANA MIHAELA CIOROIANU1, LAUREȚIU MORUȘCIAG1*, MIRON TEODOR CĂPROIU2, CARMEN LIMBAN1, ILEANA CORNELIA CHIRIȚĂ1, DIANA CAMELIA NUȚĂ1

DANA MIHAELA CIOROIANU¹, LAUREȚIU MORUȘCIAG^1*, MIRON TEODOR CĂPROIU², CARMEN LIMBAN¹, ILEANA CORNELIA CHIRIȚĂ¹, DIANA CAMELIA NUȚĂ¹