Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS AND CHARACTERIZATION OF A CARBOXYLIC ACID DERIVATIVE FOR LIPOSOMAL PREPARATIONS

CĂTĂLINA IONESCU1, SIMONA CRISTINA RIZEA1, VÉRONIQUE BARRAGAN-MONTERO2, JOHNY NEAMȚU1*

1.Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Str. Petru Rareş nr. 2-4 Craiova 200349, Dolj, România
2.Equipe SyGReM, Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247, CNRS-UM1-UM2, ENSCM, 8, rue de l’Ecole Normale, 34296 Montpellier cedex 05, France

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A new compound with cholesteryl-derived structure containing a carboxylic acid functional group has been prepared in four steps starting from cholesterol. The product has been characterized by 1H, 13C NMR and mass spectrometry analysis. It will be used for liposomal preparations, in order to evaluate the interaction of liposomes functionalized with carboxylic acid functional groups and hydroxyapatite.