Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2-HYDRAZONE-THIAZOLINE-4- ONES

OVIDIU ONIGA1, JOSEPH THIERRY NDONGO2, CRISTINA MOLDOVAN1, BRÎNDUŞA TIPERCIUC1, SMARANDA ONIGA1, ADRIAN PÎRNĂU3, LAURIAN VLASE1*, PHILIPPE VERITÉ4

1Department of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, “Iuliu Haţieganu”, University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400010 Cluj-Napoca, Romania
2Department of Organic Chemistry, University of Yaoundé I, PO.BOX 812 Yaoundé, Cameroon
3National Institute for Research and Development of Isotopic and Molecular Technologies, RO-400293 Cluj-Napoca, Romania
4Department of Analytical Chemistry, University of Medicine and Pharmacy Rouen, 22 Boulevard Gambetta, F-76183 Rouen Cedex, France

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A new series of 2-hydrazone-thiazoline-4-ones 3a-d and 2-hydrazone-5- arylidene-thiazoline-4-ones 4a-h, 5a-f and 6a-b were synthesized starting from various thiosemicarbazones by the Hantzsch condensation with chloroacetic acid. The newly synthesized compounds were screened for their antimicrobial activity against 4 strains of bacteria: Staphylococcus aureus (ATCC 29213), Bacillus subtilis (ATCC 60511), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 10145) and one fungal strain: Candida albicans (ATCC 10231). The compounds 3a-c demonstrated a good inhibitory activity against E. coli. The results of the antifungal screening showed that the 2- hydrazon-thiazolin-4-ones 3c, 3d and 4b presented an excellent activity against Candida albicans.