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STUDIES ON ACINOS ALPINUS L.: POLYPHENOLS AND TERPENOIDS COMPOUNDS PROFILE, ANTIMICROBIAL ACTIVITY, ANTIOXIDANT EFFECT AND RELEASE EXPERIMENTS ON THE ETHANOL AND PROPYLENE GLYCOL EXTRACTS

LUCIA PÎRVU ¹, FAWZIA SHA’AT ¹, RAMONA PĂVĂLOIU ¹, DENISA IOANA UDEANU ², BUJOR ALBU ^1*

1.National Institute of Chemical Pharmaceutical R&D (INCDCF), 112 Vitan Road, 031299, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Clinical Laboratory and Food Safety, 6 Traian Vuia Street, 020956, Bucharest, Romania

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The present study aims to evaluate the chemical profile, antioxidant and antimicrobial activities, as well as diffusion aspects of the active compounds (polyphenols and terpenoids) in a physiological saline solution, of two extracts from the aerial part of rock thyme, Acinos alpinus (L.) Moench. The extract in 70% ethanol (E18) was used to evaluate the chemical qualitative and quantitative composition of polyphenols and terpenoids, and to assess the scavenger activity and antioxidant properties (chemiluminescence method); the extract in 20% propylene glycol (P18) was used to test the antimicrobial effect on E. coli ATCC 8739, S. aureus ATCC 25923 and C. albicans ATCC 10231, and also in diffusion studies on Franz cell device through the use of a synthetic membrane of cellulose acetate type in physiological saline media, in order to evaluate the diffusion effectiveness of the active compounds supported on sugar and water, respectively.

« Back to Farmacia Journal 6/2019

STUDIES ON ACINOS ALPINUS L.: POLYPHENOLS AND TERPENOIDS COMPOUNDS PROFILE, ANTIMICROBIAL ACTIVITY, ANTIOXIDANT EFFECT AND RELEASE EXPERIMENTS ON THE ETHANOL AND PROPYLENE GLYCOL EXTRACTS

LUCIA PÎRVU 1, FAWZIA SHA’AT 1, RAMONA PĂVĂLOIU 1, DENISA IOANA UDEANU 2, BUJOR ALBU 1*

LUCIA PÎRVU ¹, FAWZIA SHA’AT ¹, RAMONA PĂVĂLOIU ¹, DENISA IOANA UDEANU ², BUJOR ALBU ^1*