Romanian Society of Pharmaceutical Sciences

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STONE FREE-RATE EXPERIENCE IN POST-INTERVENTIONAL PATIENTS UNDERGOING CITRATES AND PYRIDOXINE ADMINISTRATION

MIHAI ANDREI ENE 1#, VIOREL JINGA 2,3, PETRIȘOR AURELIAN GEAVLETE 1,2, COSMIN
VICTOR ENE 1,2, CĂTĂLIN ANDREI BULAI 1,2, CRENGUTA SORINA SERBOIU 2#, BOGDAN FLORIN GEAVLETE 1,2*

1“Saint John” Emergency Clinical Hospital, Urology Department, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Bucharest, Romania
3“Prof. Dr. Theodor Burghele” Clinical Hospital, Bucharest, Romania

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In order to achieve stone-free status following flexible ureteroscopy and Holmium laser lithotripsy of kidney stones, multiple remaining fragments require adjuvant treatment. This study aimed to evaluate the effectiveness of citrate and pyridoxine therapy in preventing lithiasis recurrence. Patients with kidney stones who have undergone endourological treatment were examined. We conducted a prospective, randomized trial study on 182 patients who had kidney stones up to 2 cm in diameter and received digital flexible ureteroscopy with Holmium laser lithotripsy. Afterwards, the general treatment consisted of 2 - 3 L of water per day - approximately 400 mL every four hours - and a predominantly low-protein diet. We divided them into 2 groups. Group B received only general treatment, while in Group A (92 patients), a combination of 2703 mg potassium citrate, 376 mg magnesium citrate, and 25 mg pyridoxine per sachet was added. At 90 days, the stone-free rate was higher (84.78%) in Group A compared to Group B (70.2%) (p < 0.05). It was also found that Group A had a higher expulsion rate than Group B (34.78% versus 20%, p < 0.05) and a better reduction in mean residual stone size (2.36 mm versus 1.66 mm, p < 0.05). Administration of potassium citrate, magnesium citrate, and pyridoxine provided favourable results for obtaining stone-free status after digital flexible ureteroscopy with Holmium laser lithotripsy.