« Back to Farmacia Journal 2/2014

STEREOCAULON PASCHALE LICHEN AS ANTIOXIDANT, ANTIMICROBIAL AND ANTICANCER AGENT

BRANISLAV RANKOVIĆ¹, MARIJANA KOSANIĆ^1*, TATJANA STANOJKOVIĆ²

Download Full Article PDF

In this study, antioxidant, antimicrobial and anticancer activities of the methanol extract of the lichen Stereocaulon paschale were determined by: free radical and superoxide anion scavenging activity, reducing power, determination of total phenolic compounds and determination of total flavonoid content, the minimal inhibitory concentration by the broth microdilution method against five species of bacteria and five species of fungi and the microculture tetrazolium test on FemX (human melanoma) and LS174 (human colon carcinoma) cell lines. As a result of the study methanol extract of Stereocaulon paschale had moderate free radical scavenging activity with IC50 values 879.56 μg/mL. Moreover, the tested extract had effective reducing power and superoxide anion radical scavenging. Values of minimum inhibitory concentration against the tested microorganisms ranged from 0.625 to 10 mg/mL. In addition, the tested extract had a strong anticancer activity towards both cell lines with IC50 values of 46.67 and 71.71 μg/mL.