Romanian Society of Pharmaceutical Sciences
 

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SPONGIOUS COLLAGEN-MINOCYCLINE DELIVERY SYSTEMS

MĂDĂLINA GEORGIANA ALBU1, MIHAELA VIOLETA GHICA2*

1.National Institute for Textile and Leather Research and Development, Division Leather and Footwear Research Institute, Collagen Department, 93, Ion Minulescu Str., 031215, Bucharest, Romania
2 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Physical and Colloidal Department, 6 Traian Vuia Str., 020956, Bucharest, Romania

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The purpose of the present work was to develop and characterize some spongious delivery systems based on collagen and minocycline, uncross-linked and cross-linked with glutaraldehyde, obtained at different freezing temperatures during lyophilization. The prepared sponges were analysed by scanning electron microscopy and swelling ability. The minocycline release from collagen spongious systems was investigated and the kinetic mechanism was determined. The results of this study indicated that the sponges porous architecture, their swelling and also the percentage of drug released are influenced by both sponges composition and their obtaining process.